Best Nootropics & Top Nootropic Supplements?

There are many products on the market claiming to be the best nootropics and smart drugs, but how can we tell which ones are the most effective?  That's hard to determine, because each nootropic has a different chemical make-up and what works for one person may not be what's best suited for another person.  But by research and experimentation, you will find which nootropics or nootropic stacks will be the right fit for you.

Best Nootropics

Nootropics List

Below is an extensive nooptropics list. Each nootropic has its own unique chemical make-up.  So, the best solution is to try different products and/or supplements to find a formula, or an individual nootropic supplement that will work best for you. You can build your own nootropic formula, which is known as a nootropic stack.

If you are new to nootropics, you should start with the nootropic supplements listed below or a top rated nootropic product.


Decreases anxiety and improves cognition. 
Green tea contains L-theanine which induces relaxed feelings and peace of mind.  L-theanine is an excellent natural mood enhancer.


L-tyrosine is important for the formation of norepinephrine, epinephrine, dopamine and serotonin which are the neurotransmitters that are important for regulating mood, behavior and enhancing mental alertness.


Only 10% of the population get enough choline in their diet. Choline is an extremely essential nutrient that is very important to the health of cell membranes. It's the precursor for the neurotransmitter acetylcholine. This neurotransmitter is responsible for memory.  This supplement should be taken by everyone, but especially those taking racetams.

Bacopa Monnieri

Is an herb known for its use in Ayurvedic medicine. Taken  over long time-periods, Bacopa improves cognition and helps with stress.  It helps with memory by supporting the protein network in the brain where signals are transmitted from one neuron to another. Bacosides are natural chemical compounds found in Bacopin and help to fortify Kinase, the protein in the body that replaces worn-out neurons with new ones.

Oat Straw Extract

Has many cognitive enhancement effects. It has been found to increase attention span and reduce anxiety.

Huperzine A

Is considered the most potent short term memory enhancer.  Supports memory, learning, alertness, nerve health and energy.


Supports learning, memory, and nerve cell health in certain areas of the brain.

Acetyl-L-Carnitine (ALC)

Helps the conversion of choline into acetylcholine, a key neurotransmitter.  Acetyl L-carnitine is also popular among the fitness and sports enthusiasts because of its fat burning properties and for its ability to lower cholesterol.

Dimethylaminoethonal (DMAE)

Promotes the production of the neurotransmitter, acetylcholine. 


Helps increase energy to brain cells. Also, supports microcirculation though brain capillaries and cerebral blood flow.  Vinpocetine enhances blood flow to the brain, eyes, and ears. Its effects on cerebral blood flow far exceeds all other nootropics.

St. John's Wort

St. John's wort is a  herb that was used by the ancient Greeks to treat a variety of nervous disorders.  It is now widely used as a mood enhancer and for depression.

Ginkgo Biloba Extract

Supports concentration and brain circulation. 


An amino acid that combats stress.  It elevates energy levels in the brain and increases mental alertness.

Magnesium Threonate

Helps improve short and long term memory, because it's the only magnesium that can be absorbed by the brain.


Raises dopamine and choline levels in the brain


Reduces fatigue and anxiety which reduces cortisol levels.



are a type of nootropic drug that all share a similar chemical structure. Racetrams are synthetic and are not found in food or natural sources. Racetrams are very powerful and you may have a sensitivity to them.  It is recommended that you start with a weaker, more natural nootropic, to start.  But, if you do decide to use racetrams, it would be wise to start with the weaker Piracetam and stack it with choline.
The top nootropic racetams are Aniracetam, Piracetam, Pramiracetam, Oxiracetam and Noopept.


Helps increase communication between your left and right sides of the brain, resulting in improved memory, raised alertness, learning, and mental energy.  It's currently being researched for the treatment of Alzheimer's disease.  Aniracetam is also an excellent nootropic for fighting social anxiety.  It is similar to Piracetam, but due to its fat solubility, its effects last longer and are far more potent.  Aniracetam is up to 5x stronger than Piracetam.


Although, relatively safe and used by millions of people around the world, Piracetam, it is not approved by the FDA for any medical use and it is not permitted to be sold as a dietary supplement.  But is fully legal to use, possess, import, and to be purchased online. Piracetam improves the ability to learn by boosting focus and concentration. Piracetam also has had some positive effects in older patients with dementia. Choline should always be taken with Piracetam.


There is limited data on oxiracetam because of the lack of human testing.  But many people claim that it improves memory, cognition, and that it enhances reflexes.


A very popular choice and is considered the strongest and one of the longest lasting of the racetam nootropics.  It is know for it's ability to help people remained focus on a task.  It is extremely safe, but is more expensive than the other nootropics.


Noopept is not a racetam, but is generally grouped together in the same category because it shares similar mechanisms of action with the racetam family. Noopept is 1000 times stronger than Piracetam, so be very careful when using.  It takes effect immediately while most nootropics can take weeks to work. Noopept increases memory and focus while enhancing learning.

What are Nootropics?

Nootropic is a term used to describe something which enhances the brain's cognitive function.


Nootropics are individual supplements, herbs or formula blends that come in a wide range of artificial and natural compounds that enhance cognitive function.  Nootropics are taken by anyone who wants to improve their mental performance and sharpen their cognitive skills. The different categories of nootropics are natural nootropics, racetams, vitamin B derivatives, choline nootropics, peptides, ampakines and smart drugs.  Each works in a unique way.

Joe Rogan Speaking about Alpha Brain

"The first thing that I noticed is I had a better recall of words." - Joe Rogan

How do Nootropics Work?

Nootropics work by controlling and harmonizing cerebral oxygenation, neuronal metabolism, neurotransmitter availability, increasing neurotrophic factors and by affecting other cellular processes. The exact mechanism of action will depend on the compound and the dosage.
Best Brain Drug

Neurosurgeon Martin Lazar, MD, FACS discusses the benefits of nootropics.

Nootropic Forums and Discussions

Best Nootropics


No information on this website is meant to be be construed as medical advice.  All content is for informational purposes only and should not be relied upon or as an alternative to medical advice from your doctor or other healthcare professional.  If you are suffering from a medical condition or have any specific questions about any medical matter or nootropic, please consult your doctor or other professional healthcare provider.